Protocol repository

In support of the coalition’s commitment to transparency, and with the permission of investigators, we are sharing study materials for COVID-19 clinical research, including protocols, participant information sheets and informed consent forms, case report forms, standard operating procedures, and other documents.

This material is intended to support other researchers to better understand the design and methodologies of proposed and existing studies, and to accelerate research planning by providing examples that may, where suitable, be adapted for other contexts.

If you would like to list your study on the coalition’s website, please contact us at info@covid19crc.org.

Study nameStudy typeAdditional detailsTreatment (if applicable)Study region(s)
ANTICOVRCT Phase III
Treatment of mild and moderate patients
LPV/r, hydroxychloroquine
Africa
ATOMIC2RCT Phase II/IIITreatment of moderate patients
Azithromycin
UK
CAPE CODRCT Phase IIITreatment of critical patients
Hydroxycortisone
France
CLOVID-BHRCT Phase IibTreatment of severe patients
Chloroquine
Brazil
CODEXRCT Phase IIITreatment of critical patients
Hydroxycortisone
Brazil
COPCOVRCT Phase III
Pre-exposure prophylaxisHydroxychloroquine, chloroquine
Africa, Asia, Europe
COVEPIGUiPopulation survey
SeroprevalenceN/A
Guinea
COVID-19 PEPRCT Phase III
Post-exposure prophylaxis
Hydroxychloroquine
North America
CRASH-19RCT Phase III
Treatment of hospitalised patients
Aspirin, losartan, simvastatin
Pakistan, Nigeria
CRITICAL COVID-19Cohort study
Clinical outcomes of critical patients
N/A
Multiple
DISCOVERYRCT Phase III
Treatment of severe & critical patients
Remdesivir, lopinavir/ritonavir, interferon beta 1-A, hydroxychloroquine
Europe
ModernaRCT Phase IIIVaccine trialmRNA-1273 vaccine
USA
PERICOVIDCohort study
Mother-to-child transmission
N/A
UK
RECOVERYRCT Phase III
Treatment of hospitalised patients
Lopinavir/ritonavir, dexamethasone, hydroxychloroquine, azithromycin, convalescent plasma, tocilizumab
UK
REMAP CAPRCT Phase III
Adaptative trial platform
N/AN/A
RemdesivirRCT Phase III
Treatment of moderate hospitalised patients
Remdesivir
Multiple
SEBCOVObservational, mixed methods
Survey and qualitative research
N/A
Thailand, Malaysia, Italy, Slovenia, UK
VICORCT Phase IIb
Treatment of hospitalised patients
ChloroquineVietnam

Disclaimer
Note that study-related documents posted on the COVID-19 Clinical Research Coalition (COVID-19 CRC) website have been shared by coalition members for information. Some may have been approved by Ethics Review Boards and others may still be in draft form. Documents posted here may have been further amended before being used in the conduct of the respective trials they were designed for. It is recommended that users review these documents carefully and, if they plan to use them, adapt them appropriately for their intended use. The COVID-19 CRC and its members cannot accept any liability for any claim, loss or damages as a result of any reliance placed on, or use of, these documents.