Virology, Immunology & Diagnostics
Working group objectives
- Regularly update a list, prices, and availability of validated tests (RT-PCR, serology, antigen detection etc.)
- Review, adapt, endorse, and/or validate laboratory check lists and SOPs, including sample collection, handling, and analysis
- This working group is transversal, to discuss and provide information on validated diagnostic tools and relevant SOPs, checklists, etc.
Working group members
I am a researcher at IRD, the French Research Institute on sustainable Development. In addition to IRD, my Research department, TransVIHMI, is operating under the auspices of INSERM and the University of Montpellier. My research fields of interest are emerging infectious diseases at the human/wildlife interface in developing countries: sub-Saharan Africa and South East of Asia. Specifically, my interests are focused on the animal reservoirs of viral pathogens and their cross-species transmission to humans. To address these questions, I have contributed to the development and transfer to African countries, of serological and molecular detection tools for multiple viral infections. I mentored several students from Europe, Africa, South East of Asia and South America at master and PhD levels. I have contributed to more than 100 peer-reviewed papers and participated to tens of international scientific conferences.
Mirela d’Arc has a Bachelor in Biology from Universidade Federal de Pernambuco (Brazil, 2007), a master in Genetics from Universidade Federal do Rio de Janeiro – UFRJ (Brazil, 2010), and two PhDs, one in Genetics from UFRJ (Brazil, 2014) and another in Biology for Health from Université de Montpellier (France, 2015).
She has worked as a substitute teacher at UFRJ and, is currently undertaking a post-doctoral fellowship in the Department of Genetics (UFRJ). She has experience in Genetics, Virology, and Bioinformatic.
Dr Aruna Dharshan De Silva is currently Head of the Biomedical Lab-2 and a Senior Lecturer in the Department of Paraclinical Sciences, Faculty of Medicine, General Sir John Kotelawala Defense University (KDU), Sri Lanka. In addition, he holds an Adjunct Associate Professor position at the La Jolla Institute of Allergy & Immunology, California, USA. He serves as a visiting lecturer in Immunology at IBMBB, University of Colombo.
He is currently the Chairman of the Working committee on Biotechnology at the National Science Foundation, Sri Lanka.
Dr De Silva was the former Director of KDU-CARE from 2017 Nov, till Nov 2019. Before that he was the Director and Senior Scientist at the Genetech Research Institute from 2008 to 2017.
Dr De Silva obtained his PhD in Microbiology and Immunology from Pennsylvania State University College of Medicine, USA (2000). He has over 10 years of overseas experience working at top –level infectious disease and immunology laboratories and has over 60 international publications.
He has run research labs in Sri Lanka over the last 12 years and conducts research with grants from foreign and local funding agencies to study Dengue, COVID-19, Tuberculosis & the rare disease Melioidosis.
Dr. Shymaa Enany is an associate professor of Microbiology, Suez Canal University, Egypt. She received her PhD from School of Medical Sciences, Niigata University, Japan. Her postdoc was in USA and Japan. She was the first Arab scientist applying microbial proteomic techniques helping in revealing good markers for bacteria spreading in community.
She received many awards for her scientific contributions. Recently, she awarded the most prestigious award in Egypt; the state encouragement prize for women in the field of health and pharmaceutical sciences, 2019. Also, she was awarded The World Academy of Sciences (TWAS) Young Arab Scientist Prize 2018 for Scientific Achievement in Medical Sciences. She was selected as a member of Egyptian Young Academy of Science, an evaluator on Academy of Scientific Research and Technology, a reviewer in International Exhibition of Innovation, and an affiliate of The World Academy of Sciences.
Dr Shymaa is also one of scientific committee of World Forum for Women in Science, a selected young leader in STS and WSF, a member in the global Open Science Group, and a collaborator in Global Burden of Disease.
She is one of Microbiology National Committee working for achieving sustainable development goals for a better future. She was appointed as an Egyptian ambassador in Next Einstein Forum (NEF), which showcase the global contribution and potential of scientists from Africa that enabling Africa to get onto the global scientific stage. Latterly, she is selected as an African science leadership program fellow.
Dr. Winters Muttamba is a public health research scientist, and currently a research fellow at Makerere University Lung Institute. He has special interest in research on lung health related illnesses; mainly TB, Asthma, COPD and COVID-19. He has previously been involved in Xpert MTB/RIF evaluation studies that informed country wide rollout as well as economic evaluations for TB care in Uganda. As Project Manager of the African Severe Asthma Project (ASAP), he contributed to establishment of the single largest cohort of Asthma patients in Eastern Africa. He was involved in setting up the COVID-19 research group (COVIDRES) at Makerere University Lung Institute where he is involved in COVID-19 epidemiology and therapeutic research studies including the COVID-19 Convalescent Plasma trial. He sits on the in-country technical working group of the East African Public Health Laboratory Networking Project.
Wolfgang Preiser is a medical virologist who specialised in his home town Frankfurt, Germany, and at University College London. He received his second doctoral degree (Habilitation) in 2005 while working as consultant virologist in Frankfurt.
Dr Wilber Sabiiti is Senior Research Scientist at the University of St Andrews specialising in translational diagnostics and antimicrobial resistance research. His research group applies interdisciplinary approaches to maximise uptake and utilisation of diagnostic and treatment tools into policy and practice with special focus on low- and middle- income countries. He co-leads the development and translation of the first molecular test that quantifies tuberculosis bacterial load in hours to monitor response to anti-TB therapy. He graduated with BSc Biochemistry from Makerere University Uganda, MSc Molecular biology from Vrije Univerteit Brussel Belgium and PhD from University of Birmingham UK.
COVID-19 Diagnostics: Their applications and key unanswered questions in low-resource settings
Clinical Microbiologist specialized at University of Witwatersrand in Johannesburg, South Africa.
Currently based at one of the largest hospitals globally, Chris Hani Baragwanath Academic Hospital, providing services from a Microbiology laboratory as a specialist microbiologist and infection prevention practitioner.
Eager to participant in diagnostics development pertaining to COVID-19
I am a medical doctor with graduate training (MSc, Fellowship, PhD) in a diverse array of basic science fields (Immunology, Vaccinology, Clinical Microbiology, Genetics and Filovirology). I also hold expert skills-training in Bioentrepeneurship and R & D. Over the past 10 years, I have served as In-Charge of the Unit of Genetics & Genomics (a super-specialized referral centre for children and adults born with rare, Mendelian disease at the Mulago National Reference and Teaching Hospital Complex, Kampala, Uganda). I am member of the African Society for Human Genetics (AfSHG) and Ex-Chair of the Education and Coordinated Working Group (ECTWG) of the H3Africa Consortium. My research interests’ center on pathogen OMICS:-with a focus on identifying new molecular targets for research and development of diagnostics, therapeutics and vaccines. My group has identified, patented and validated reagents (B cell-eptopes, synthetic peptides, recombinant EBOV glycoprotein, monoclonal and polyclonal antibodies, and aptamers) for the R & D of 3 prototypes of a pan-filovirus rapid diagnostic tests-RDTs (Ag, IgM and IgG). Over the past 10 years, we have not only built the necessary expertise and experience, but have also established an ecosystem of partners from across the academia, industry and public private partnerships. For this work and its impact on the 2013-to 2016 EVD outbreak in West Africa, I was listed as # 57 of the 100 most influential Africans of 2015. In 2019, my team won 1st Prize for the WHO innovation Challenge (Product Development), and I was nominated as REACH /RLM finalist. I am current (2019-2020) TWAS-SAREP Young Scientist award winner (Infectious Diseases. I chair the Uganda’s Scientific Advisory Committee on CoVID19 for the Ministry of Health and National Task Force.
Dr. Woods is a professor in the Departments of Medicine and Pathology at Duke University, adjunct associate professor in Epidemiology at the University of North Carolina-Chapel Hill School of Public Health, and adjunct associate professor in the Emerging Infections Program at the Duke-National University of Singapore Graduate Medical School. He is Executive Director of the Hubert-Yeargan Center for Global Health, and Associate Director for Applied Genomics in the Duke Center for Applied Genomics & Precision Medicine (CAGPM). Dr. Woods is the Global Health lead for the Duke Tropical Conservation Initiative. Clinically, he is Chief of Infectious Diseases, and hospital epidemiologist for the Durham VA Medical Center. Dr. Woods is board-certified in internal medicine, infectious diseases, and medical microbiology.
Dr. Woods has co-authored over 180 peer-reviewed articles. His research focuses on development of novel diagnostic approaches to infectious disease and potential for interspecies transmission of pathogens. His genomic approach to harnessing the host response for diagnosis of infectious diseases has been called a paradigm shift in the field. He is particularly interested in augmenting medical microbiology capacity in the developing world and epidemiology of emerging and re-emerging infectious diseases.